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Adnan Ali Khalaf Alrubaye

Adnan Ali Khalaf Alrubaye

Research Assistant Professor and Associate Director of the Cell and Molecular Biology Program

J. William Fulbright College of Arts & Sciences

(BISC)-Biological Sciences

Phone: 479-575-2095

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Dept. of Poultry Science and Biological Sciences

1260 W. Maple Street

Office: POSC O-413 | Lab: POSC-L 415

Fayetteville, AR 72701

Office: 479-575-2095 | lab: 479-575-5645 | fax: 479-575-2583

E-mail: aakhalaf@uark.edu

  • Microbiology of Bacterial Chondronecrosis and Osteomyelitis in Broilers
  • Bacterial culturing, PCR and sequencing to genotype isolates for 16S rDNA
  • Understanding the pathogenesis of Bacterial Chondronecrosis and Osteomyelitis
  • Bacterial Chondronecrosis with Osteomyelitis leading to Lameness:  Our research group is investigating the causes, epidemiology, transmission, and prevention of bacterial infections BCO lameness in chickens.  We use a wire flooring system developed by Dr. Robert Wideman and the bacterial challenge with Staphylococcus agnetis to induce lameness. We have worked with several industry partners to try to identify feed additives that can help reduce the incidence of BCO lameness in broilers.

  • General Microbiology 
  • Prokaryote Biology
  • Principles of Biology

General microbiology

 Principles of Biology

Prokaryote Biology

 Human Physiology

 

 

BVMS- June 2000; University of Baghdad

M.Sc.- February 2003; University of Baghdad

M.Ed.- May 2013; University of Arkansas

Ph.D.- May 2013; University of Arkansas

Professoriate Graduate Certificate- August 2011; University of Arkansas

Greene, E., Flees, J., Dhamad, A., Alrubaye, A., Hennigan, S., Pleimann, J., Smeltzer, M., Murray, S., Kugel, J., Goodrich, J. and Robertson (2019). Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis. The American journal of pathology, 189(10), 2077-2089.

Al-Rubaye A.A.K., N.S. Ekesi, S. Zaki, N.K. Emami, R.F. Wideman Jr, D.D. Rhoads. (2017). Chondronecrosis with Osteomyelitis in Broilers: Further Defining a Bacterial Challenge Model Using the Wire Flooring Model.  Poultry Science 96:332–340. doi: 10.3382/ps/pew299

Al-Rubaye, A. A. K., M. B. Couger, S. Ojha, J. F. Pummill, J. A. Koon, II, R. F. Wideman, Jr. and D. D. Rhoads (2015). Genome Analysis of Staphylococcus agnetis, an Agent of Lameness in Broiler Chickens. PLoS ONE 10(11): e0143336.

Al-Rubaye, A. A. K.,; Nnamdi S. Ekesi; Sura Zaki; Nima K. Emami; Robert F. Wideman Jr; Douglas D. Rhoads Chondronecrosis with osteomyelitis in broilers: Further defining a bacterial challenge model using the wire flooring model. Poultry Science 2016;
doi: 10.3382/ps/pew299.

Wideman, R. F., Al-Rubaye, A., Kwon, Y. M., Blankenship, J., Lester, H., Mitchell, K. N. & Schleifer, J. (2015). Prophylactic administration of a combined prebiotic and probiotic, or therapeutic administration of enrofloxacin, to reduce the incidence of bacterial chondronecrosis with osteomyelitis in broilers. Poultry science, 94(1), 25-36.

Wideman Jr., R. F., Al-Rubaye, A., D. Reynolds, D. Y., Lester, H., Spencer, C., Hughes, J. M., & Pevzner, a. I. Y. (2014). Bacterial chondronecrosis with osteomyelitis in broilers: Influence of sires and straight-run versus sex-separate rearing. Poultry science, 93(7), 1675-1687.

Wideman, R. F., Al-Rubaye, A., Gilley, A., Reynolds, D., Lester, H., Yoho, D.& Pevzner, I. (2013). Susceptibility of 4 commercial broiler crosses to lameness attributable to bacterial chondronecrosis with osteomyelitis. Poultry science, 92(9), 2311-2325.

Krishnamoorthy, S., Smith, C. D., Al-Rubaye, A. A., Erf, G. F., Wideman, R. F., Anthony, N. B., & Rhoads, D. D. (2014). A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines. Poultry Science, 93(2), 307-317 .

Mandal1, R. K. Jiang1, T.  Alrubaye, A. A., Rhoads, D. D., Wideman Jr., R. F., Zhao, J., Pevzner, I.,  and Kwon1, Y. M. (2016). Bacteremia and Lameness: An investigation into blood microbiota associated with Bacterial Chondronecrosis with Osteomyelitis (BCO) in Broilers. Scientific 

  1. Alrubaye, A.A. (invited speaker). Recent Findings on BCO Lameness, Zinpro International Conference, Chicago, August 2019.
  2. Alrubaye, A.A. (invited speaker). Reduction of the presentation of lameness in broilers, Mexico, August 2019.
  3. Alrubaye A.A., Ekesi, N., Hassan, A, Elkins, E., D. Rhoads. Improving Bone Health and Protection against Bacterial Chondronecrosis with Osteomyelitis using Micronutrients and Genetic Selection. Plant and Animal Genome Conference, 2019.
  4. Greene ES, J Cook, R Liyanage, A Alrubaye, S Hennigan, J Pleimann, D Rhoads, R Wideman, S Dridi. Proteomics Analysis of Bacterial Chondronecrosis with Osteomyelitis (BCO) Lesions in Broiler Tibia. Poultry Science Association, San Antonio, TX, July 2018.
  5. Greene ES, A Alrubaye, S Hennigan, J Pleimann, D Rhoads, R Wideman, S Dridi. DICER1 dysregulation and dsRNA accumulation in BCO chickens. Poultry Science Association, San Antonio, TX, July 2018.
  6. Shwani A, N Ekesi, S Zaki, A Al-Rubaye, P Adkins, M Calcutt, J Middleton, and D Rhoads. Phylogenomic comparison of Staphylococcus agnetis isolates from dairy cattle mammary glands and bacterial chondronecrosis with osteomyelitis in broilers. Plant and Animal Genome XXV, San Diego, CA, January 2018.
  7. Douglas Rhoads, Sura Zaki, Abdulkarim Shwani, Nnamdi Ekesi, Amer Hasan, and Adnan Alrubaye. Directed Genome Evolution to Investigate Macrophage Survival and Killing by a Staphylococcus Isolate that Induces Chondronecrosis with Osteomyelitis in Chickens.
  8. A Alrubaye, D Koltes, and DD Rhoads (2017) Experiment 24: Evaluation of Hansen probiotics for protection against BCO lameness on litter with exposure to Staphylococcus agnetis. Chr Hansen December 2017.
  9. Al-Rubaye A.A., S. Zalo, N. Ekesi, A. Shwani, R. F. Wideman, D. Rhoads Staphylococcus agnetis involvement in Bacterial Chondronecrosis with Osteomyletis in Broilers. Arkansas Biosciences Institute conference, Little Rock, AR, Sep 2016.
  10. Al-Rubaye A.A., S. Zalo, N. Ekesi, A. Shwani, R. F. Wideman, Y. M. Kwon, D. D. Rhoads Genetic and genomic analyses of Staphylococcus agnetis an agent of Bacterial Chondronecrosis with Osteomyelitis in Broilers. Arkansas Bioinformatics Consortium conference, Little Rock, AR, April 2016.
  11. Al-Rubaye A.A. (invited speaker). 2015 US Live Production and Welfare seminar speaker Bacterial Chondronecrosis and Osteomyelitis (BCO) / Leg Problems. Nashville, Tennessee, Sep 2015.
  12. A. K. Al-Rubaye, D. D. Rhoads, and R. F. Wideman, University of Arkansas. Genetic and Genome Analyses of Bacteria Cultured from Lame Broilers with Osteomyelitis. Plant and Animal Genome Conference XXIII, San Diego, CA, Jan 2015.
  13. A. K. Al-Rubaye, D. D. Rhoads, and R. F. Wideman. Genetic and genome analyses of bacteria cultured from lame broilers with osteomyelitis??. Poultry Science Association Conference, Louisville, KY, July 2015.
  14. Academic awakening faculty panel tomorrow for REAL world_ Center for Multicultural and Diversity Education Aug 22, 2015. Panel Discussion.
  15. A. K. Al-Rubaye, D. D. Rhoads, and R. F. Wideman, University of Arkansas. Genetic and genome analyses of bacteria cultured from lame broilers with osteomyelitis. Gut Health Symposium, St Louis, Mo, Nov 2014.
  16. A A. Al-Rubaye, K. Estill,  R.F. Wideman, D.D. Rhoads. 16S rRNA Based Diagnosis and Whole Genome Sequencing of Bacteria Cultured from Lame Broilers with Osteomyelitis. South Central Branch of American Society of Microbiology conference, Fayetteville, AR, September 2014.
  17. A A. Al-Rubaye, K. Estill,  R.F. Wideman, D.D. Rhoads. 16S rRNA Based Diagnosis and Whole Genome Sequencing of Bacteria Cultured from Lame Broilers with Osteomyelitis. Poultry Science Association Conference, Corpus Christi, TX, July 2014.
  18. A A. Al-Rubaye. 16S based diagnosis of bacteria involved in BCO in Chickens. Cell and Molecular Biology Seminar Series, University of Arkansas, Fayetteville, Feb 2014.
  19. A A. Al-Rubaye. 16S based diagnosis of bacteria involved in BCO in chickens. Sigma XI Society Seminar, University of Arkansas, Fayetteville, Feb 2014.
  20. A A. Al-Rubaye, S Ojha, R.F. Wideman, D.D. Rhoads. Molecular Identification of Bacteria Involved in Lameness in Broiler. Plant and Animal Genome Conference XXII, San Diego, CA, Jan 2014.
  21. A A. Al-Rubaye, S Ojha, R.F. Wideman, D.D. Rhoads. Molecular Identification of Bacteria Involved in Lameness in Broiler. Poultry Science Association Conference, San Diego, CA, July 2013.
  22. A A. Al-Rubaye, S Ojha, R.F. Wideman, D.D. Rhoads. Molecular Identification of Bacteria Involved in Lameness in Broiler. Plant and Animal Genome Conference, San Diego, CA, Jan 2013.
  23. A A. Al-Rubaye, S Ojha, R.F. Wideman, D.D. Rhoads. Molecular Identification of Bacteria Involved in Lameness in Broiler. From Abstract to Contract Graduate school posters competition, FEB 2013.
  24. A A. Al-Rubaye, S Ojha, R.F. Wideman, D.D. Rhoads. Molecular Identification of Bacteria Involved in Lameness in Broiler. Plant and Animal Genome Conference, San Diego, CA, Jan 2013.
  25. A.A. Al-Rubaye, NB Anthony, GF Erf, RF Wideman, DD Rhoads.  Investigation of Three Candidate Genes Related to Pulmonary Hypertension Syndrome in the Chicken using Quantitative PCR.  Plant and Animal GENOME (PAG XX), San Diego, CA, Jan 2012.
  26. A.A. Al-Rubaye, NB Anthony, GF Erf, RF Wideman, DD Rhoads.  Investigation of Three Candidate Genes Related to Pulmonary Hypertension Syndrome in the Chicken using Quantitative PCR.  Poultry Science Association Conference, St. Louis, MO, July 2011.
  27. A.A. Al-Rubaye, NB Anthony, GF Erf, RF Wideman, DD Rhoads.  Investigation of Three Candidate Genes Related to Pulmonary Hypertension Syndrome in the Chicken using Quantitative PCR.  University of Arkansas Graduate School Posters Competition, Fayetteville, AR, Feb 2011.
  28. A.A. Al-Rubaye, NB Anthony, GF Erf, RF Wideman, DD Rhoads.  Investigation of Three Candidate Genes Related to Pulmonary Hypertension Syndrome in the Chicken using Quantitative PCR.  Plant and Animal GENOME, San Diego, CA, Jan 2011.
  29. A.A. Al-Rubaye, NB Anthony, GF Erf, RF Wideman, DD Rhoads.  Investigation of Three Candidate Genes Related to Pulmonary Hypertension Syndrome in the Chicken using Quantitative PCR.  Poultry Science Association, Denver, CO, July 2010.
  30. A.A. Al-Rubaye, NB Anthony, RF Wideman, and DD Rhoads. Using Quantitative PCR to Investigate Three Candidate Genes Related to Pulmonary Hypertension in the Chicken.  Plant and Animal Genome, San Diego, CA, Jan 2010.
  31. A.A. Al-Rubaye, S Krishnamoorthy, N Anthony, GF Erf, RF Wideman, DD Rhoads. Genetic Analysis of Pulmonary Hypertension and Ascites in the Chicken.  USDA NC1170 workshop, San Diego, CA, Jan 2010.
  32. Candace .D. Smith, A.A. Al-Rubaye, N.B. Anthony, G.F. Erf2, R.F. Wideman, Douglas .D. Rhoads. Using Quantitative PCR To Investigate Three Candidate Genes Related To Pulmonary   Hypertension In The CHICKEN. Plant and Animal Genome Conference San Diego, CA Jan 2009.
  33. Sriram Krishnamoorthy, A.A. Al-Rubaye, Nyoman Fitri, Candace Smith3, J.Russell Burks, Anna Leu, N.Brooke Peeples, Allison Chinn, Patrick Greenburg, Gisela F. Erf, Robert  F. Wideman. Pulmonary arteriole hypertension in the chicken: Genetic and histopathological similarities to human. ABI conference. Little Rock, AR Sep. 29 2010.
  34. A.A. Al-Rubaye Investigation of Four Candidate Genes Related to Pulmonary Hypertension Syndrome in the Chicken using Quantitative PCR. Poultry Genomics workshop, Plant and Animal Genome (PAG XX), San Diego, CA, Jan 2012.

2019                   Fulbright College Master Teacher Award

2019                   The Collis Geren Award for excellence in graduate and international education

2019                   The UA Associated Students Government (ASG) Outstanding Faculty Member

2018                   The Provost’s “Not-So-New” Faculty Commendation for Teaching Commitment

2018                   Nominated for the Fulbright Master Teacher award

2017                   Nominated for the Fulbright Master Teacher award

2016                   The Dr. John Imhoff Outstanding Research Publication Award

2016                   Most Outstanding Faculty Member Nomination

2015                   The Provost’s New Faculty Commendation for Teaching Commitment

2014                   The University of Arkansas’ Individual Diversity Award

2013                   Aubrey E. Harvey Outstanding Graduate Research Award

2013-present   Vice President and Secretary, University of Arkansas Chapter, Sigma Xi 

2011                  Delbert Swartz Fellowship for Outstanding Graduate Student

2011                  Biology Graduate Students Association President

2008-2013        Iraqi Graduate Students Association President, USA.