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Xiaolun Sun

Xiaolun Sun

Assistant Professor

Dale Bumpers College of Agricultural, Food & Life Sciences

(POSC)-Poultry Science

Phone: 479-575-2322

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My overall research interest is to understand the dynamic interaction among host cellular events, molecular signaling, intestinal microbiome, and bacterial pathogens during health and disease and to identify signaling pathways and microbiome which attenuate microbe-mediated intestinal diseases in human and poultry. I employ poultry and murine models to dissect the complex interaction. Specifically, my laboratory focuses on the following areas of biomedical and poultry research: (A) Poultry production, microbiome, and C. jejuni transmission and pathogenesis; (B) Microbiome and host cellular and molecular signaling in microbe-induced intestinal diseases such as necrotic enteritis in poultry and human inflammatory bowel diseases.

POSC/ANSC 5962 Gastrointestinal/Digestive Physiology of Domestic Animals, Fall.

2007     Ph.D.   Animal and Poultry Sciences,  Virginia Tech, VA, Blacksburg              
2004     MS      Animal and Poultry Sciences,   Virginia Tech, VA, Blacksburg             
1990    BS       Poultry Disease Control & Husbandry             Southern China Agricultural University, Guangzhou, China

Sun, X., Winglee, K., Gharaibeh, R., Gauthier, J.,  He, Z., Tripathi, P., Avram, D., Bruner, S., Fodor A., and Jobin, C. 2018. Microbiota-derived Metabolic Factors Reduce Campylobacteriosis in Mice. Gastroenterology. 154 (6):1751-1763.e2. DOI: https://doi.org/10.1053/j.gastro.2018.01.042. (Co-corresponding author)

Jia, Z, Anandh, V., Chen, W, and Sun, X. 2018. Natural Products Targeting on Oxidative Stress and Inflammation: Mechanisms, Therapies, and Safety Assessment. Oxid Med Cell Longev. doi: 10.1155/2018/6576093.

Tomkovich, S., Yang, Y., Winglee, K., Gauthier, J., Mühlbauer, M., Sun, X., Mohamadzadeh, M., Liu, X., Martin, P., Wang, G., Oswald, E., Fodo,r A. and Jobin, C. 2017. Locoregional effects of microbiota in a preclinical model of colon carcinogenesis. Cancer Res. 77(10): 2620-2632. doi: 10.1158/0008-5472.CAN-16-3472.

Sun, X. and Jobin, C. 2014. Nucleotide-binding oligomerization domain-containing protein 2 controls host response to Campylobacter jejuni in Il10−/- mice. J Infect Dis. 210(7):1145-54. doi: 10.1093.

Kanther, M., Tomkovich, S., Sun, X., Grosser, MR., Koo, J., Flynn, EJ. 3rd, Jobin, C., Rawls, JF. 2014. Commensal microbiota stimulate systemic neutrophil migration through induction of Serum amyloid A. Cell Microbiol. doi: 10.1111/cmi.12257.

Sun, X. and Uronis, J. 2013. Bacterial mediated gastrointestinal inflammation. Methods Mol Biol. 1031:197-202. doi: 10.1007/978-1-62703-481-4_22

Sun, X., Liu, B., Sartor, RB., Jobin, C. 2013. Phosphatidylinositol 3-kinase-γ signaling promotes Campylobacter jejuni-induced colitis through neutrophil recruitment in mice. J Immunol. 190(1):357-65. doi: 10.4049/jimmunol.1201825. Epub 2012 Nov 23. PMCID: PMC3529774

Sun, X. and Jia, Z. 2012.  A brief review of biomarkers for preventing and treating cardiovascular diseases. J Cardiovasc Dis Res. 2012 Oct (4):251-4. doi: 10.4103/0975-3583.102688.

Sun, X., Threadgill D. and Jobin, C. 2012. Campylobacter jejuni induces colitis through activation of mammalian target of rapamycin signaling pathway. Gastroenterology Jan; 142(1):86-95.e5. Epub 2011 Oct 1. PMCID: PMC3253301

Kanther, M., Sun, X., Mühlbauer, M., Mackey, LC., Flynn, EJ 3rd., Bagnat, M., Jobin, C., Rawls, JF. 2011 Microbial colonization induces dynamic temporal and spatial NF-κB responses in gnotobiotic zebrafish. Gastroenterology. Jul;141(1):197-207. Epub 2011 Mar 24. PMCID: PMC3164861

Lippert, E., Karrasch, T., Sun, X., Allard, B., Herfarth, H., Threadgill, D., Jobin, C. 2009. Gnotobiotic IL-10-/-; NF-?BEGFP Mice Develop Rapid and Severe Colitis Following Campylobacter jejuni Infection. PLoS ONE 4(10): e7413. doi:10.1371/journal.pone.0007413. PMCID: PMC2760752

Troche, C., Sun, X., McElroy, A., Remus, J., and Novak, C. 2007. Supplementation of Avizyme 1502 to corn soy-bean meal-wheat diets fed to turkey tom poults: The First Fifty-Six Days of Age. Poult. Sci. 86: 496-502.

 

Sun, X., McElroy, A., Webb Jr, K. E., Sefton, T., and Novak, C. 2005.  Broiler performance and intestinal alterations when fed drug-free diets. Poult. Sci. 84: 1294 – 1302.

2016-   Assistant Professor, Center of Excellence for Poultry Science, University of Arkansas, AR

2013 - 2016  Research Assistant Professor, Department of Medicine, University of Florida, Gainesville, FL

2008-2013 Postdoctoral Research Associate, Department of Medicine, CGIBD, University of North Carolina at Chapel Hill, NC   

2002-2007  Graduate Fellow, Virginia Tech, Blacksburg, VA

2000-2001  Manager, Shanghai DCH Jiangnanfeng Co. Ltd., Shanghai, China    

1990-2000  Manager, Hefei Chia Tai Co. Ltd., Heifei, China

2015  Outstanding Research Award, Department of Medicine, University of Florida

2008  Travel Scholarship for training in inflammatory bowel disease research, Crohn's & Colitis Foundation of America

2007  Poster award in Dean's Forum on Health, Food, and Nutrition for research excellence in nutrition research, College of Agriculture and Life Sciences, Virginia Tech

2004  JAR travel Fellowship for training and research excellence in animal science research, Dept. of Animal and Poultry Sciences, Virginia Tech

2002-2007  Pratt Graduate Fellowship for excellence in graduate study, Dept. of Animal and Poultry Sciences, Virginia Tech